Bioactive Small Molecules
Selleck Chemical LLC Polatuzumab vedotin-piiq-1MG
Polatuzumab vedotin-piiq (polatuzumab vedotin DCDS4501A RG7596) is an antibody-drug conjugate (ADC) composed of a monoclonal antibody against CD79b (a B cell receptor component) and the anti-mitotic cytotoxic agent monomethyl auristatin (MMAE) It is used for the treatment of relapsed/refractory diffuse large B-cell lymphoma (DLBCL)
Selleck Chemical LLC GSK3685032-E1046-5MG
GSK3685032 is a non-time-dependent highly selective enzymatic inhibitor of DNA methyltransferase (DNMT1) with IC50 of 0 036 M and over 2500-fold more selective than DNMT3A/3L and DNMT3B/3L
Biotium Heparan Sulphate Proteoglycan(A7L6), CF568 conjugate, 0.1mg/mL
This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan's strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other
Medchemexpress LLC KVS0001 | 3056394-59-0 | 99.1% | 579.07 | 50 MG
KVS0001 is a selective SMG1 inhibitor that elevates the expression of transcripts and proteins resulting from truncating mutations. It increases the presentation of immune-targetable HLA class I-associated peptides from nonsense-mediated decay (NMD)-downregulated proteins on the surface of cancer cells. This compound exerts anti-tumor properties and can be studied in research for NMD-related diseases, including cancer and inherited diseases.
- Inhibits SMG1 protein more selectively than other kinases.
- Subverts nonsense-mediated decay (NMD)-mediated downregulation of mutant transcripts and proteins.
- Increases interferon-gamma (IFN-γ) release and killing of target cancer cells.
- Significantly increases RNA in genes with truncating mutations.
- Slows tumor growth in C57BL/6N and BALB/c mouse models.
- Increases transcript levels in genes with truncating mutations in xenograft tumors.
Medchemexpress LLC Argadin | 289665-92-5 | 98.7% | 674.71 | 1 MG
Argadin is a cyclopentapeptide chitinase inhibitor that inhibits chitinase B (ChiB).
- Inhibits chitinase B (ChiB) with a Ki value of 20 nM.
- Can be used for research related to fungicides.
- Can be used for research related to insecticides.
Medchemexpress LLC (Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) | 129622-68-0 | 99.3% | 3478.06 | 5 MG
(Asn10,Leu11,D-Trp12)-pTH-Related Protein (7-34) amide (human, mouse, rat) is a potent PTH-1R antagonist, showing no partial agonist activity. It completely blocks the antioxidant effect of PTHrP(1-37) in mouse osteoblast MC3T3-E1 and primary human osteoblasts, confirming PTH1R activation as the main signaling mechanism for the antioxidant effect of PTHrP(1-37).
- Potent PTH-1R antagonist
- Does not display any partial agonist activity
- Blocks antioxidant effect of PTHrP(1-37) in osteoblast cells
- Relevant for research on PTH1R signaling
Medchemexpress LLC BMS-303141 | 943962-47-8 | 99.0% | 424.30 | 50 MG
BMS-303141 is a potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM. It is intended for research use only and is not sold to patients.
- Potent, cell-permeable ATP-citrate lyase (ACL) inhibitor with an IC50 of 0.13 μM.
- In HepG2 cells, shows inhibition of total lipid synthesis with an IC50 of 8 μM.
- Exhibits no cytotoxicity up to 50 μM in a cell-based Alamar Blue cytotoxicity assay.
- In high-fat fed mice, lowers plasma cholesterol and triglycerides by approximately 20-30%.
- Reduces fasting plasma glucose by 30-50% in high-fat fed mice.
- Shows gradual inhibition of weight gain and reduction in adiposity without affecting food intake.
- Has an oral bioavailability of 55% and a half-life of 2.1 hours.
Medchemexpress LLC Nisin Z | 137061-46-2 | 3331.05 | 1 G
Nisin Z is an antimicrobial and anti-inflammatory peptide effective against Gram-positive bacteria and fungi, including C. albicans. This product is intended for research use only.
- Antimicrobial and anti-inflammatory peptide
- Effective against Gram-positive bacteria
- Effective against fungi, such as C. albicans
- Increases gingival fibroblasts detachment and differentiation
- Decreases C. albicans adhesion to gingival cells
- Inhibits germ tube formation by C. albicans
- Reduces production of LPS-induced pro-inflammatory cytokines
- Inhibits activation of ERK1/2 and p38 MAPK signaling pathway
- Prevents pathological damage in mastitis mouse model
Medchemexpress LLC Suc-Ala-Phe-Lys-AMC | 73207-91-7 | 99.8% | 621.68 | 10 MG
Suc-Ala-Phe-Lys-AMC is a highly sensitive fluorogenic substrate used for plasmin and assaying gingipain K.
- High sensitivity for plasmin
- Suitable for assaying gingipain K
- White to off-white appearance
- Powder form
- Soluble in DMSO
Medchemexpress LLC BAY 249716 | 696628-24-7 | 99.0% | 288.76 | 5 MG
BAY 249716 stabilizes all three p53 protein variants. It also exhibits antitubercular activity with an IC90 of <0.10 μg/mL for Tuberculosis. This product is for research use only and not for sale to patients.
- Stabilizes all three p53 protein variants.
- Exhibits antitubercular activity with an IC90 of <0.10 μg/mL for Tuberculosis.
- Antileishmanial activity against Leishmania donovani in mouse J-774A1 cells (IC50: 0.09 μM).
Medchemexpress LLC Gepotidacin | 1075236-89-3 | 99.9% | 448.52 | 5 MG
Gepotidacin is a novel triazaacenaphthylene bacterial type II topoisomerase inhibitor. It is a first-in-class antibacterial that inhibits bacterial DNA gyrase and topoisomerase IV through a unique mechanism. It demonstrates in vitro activity against a broad spectrum of gram-negative and gram-positive bacteria, including drug-resistant strains.
- Novel triazaacenaphthylene bacterial type II topoisomerase inhibitor
- Inhibits bacterial DNA gyrase and topoisomerase IV
- Effective against gram-negative and gram-positive bacteria
- Active against drug-resistant bacterial strains
- Targets pathogens associated with conventional and biothreat infections
Medchemexpress LLC Nisin Z | 137061-46-2 | 97.1% | 3331.05 | 5 G
Nisin Z is an antimicrobial and anti-inflammatory peptide effective against Gram-positive bacteria and fungi, including C. albicans. It demonstrates a range of biological activities in both in vitro and in vivo models.
- Increases gingival fibroblasts detachment and differentiation.
- Decreases C. albicans adhesion to gingival cells.
- Inhibits germ tube formation by C. albicans.
- Reduces production of LPS-induced pro-inflammatory cytokines.
- Inhibits activation of ERK1/2 and p38 MAPK signaling pathway.
- Reduces C. albicans growth in cell viability assays.
- Inhibits phosphorylation of p38 and ERK1/2.
- Prevents pathological damage in mastitis mouse models.
- Reduces inflammatory cell infiltration and cytokine levels.
Medchemexpress LLC Cagrilintide | 1415456-99-3 | 100.0% | 4409.01 | 5 MG
Cagrilintide is an investigational novel long-acting acylated amylin analogue. It acts as a nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake, showing potential for obesity research.
- Investigational novel long-acting acylated amylin analogue
- Acts as a nonselective amylin and calcitonin G protein-coupled receptor agonist
- Induces significant weight loss and reduces food intake
- Potential for obesity research
- White to off-white solid appearance
- Soluble in H2O at 100 mg/mL (requires ultrasonic)
- Store powder at -80°C for 2 years or -20°C for 1 year (sealed, dry, under nitrogen)
- Store solutions at -80°C for 6 months or -20°C for 1 month (sealed, dry, under nitrogen)
Medchemexpress LLC Z-Gly-Pro-Arg-AMC hydrochloride | 201928-42-9 | 99.15% | 656.13 | 5 MG
Z-Gly-Pro-Arg-AMC hydrochloride is a fluorescent trypsin and cathepsin K substrate. It is used to determine trypsin and cathepsin K activity.
- Fluorescent trypsin and cathepsin K substrate
- Can be used to determine trypsin and cathepsin K activity
- For research use only
Medchemexpress LLC Deschloroclozapine dihydrochloride | 99.9% | 365.30 | 100 MG
Deschloroclozapine dihydrochloride, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. It binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.
- Highly potent muscarinic DREADDs agonist.
- Binds to DREADD receptor subtypes hM3Dq and hM4Di.
- Developed as a promising PET tracer for DREADD imaging.