Bioactive Small Molecules
Medchemexpress LLC HY-138153 5mg , JKE-1674 CAS:2421119-60-8 Purity:>98%
HY-138153 5mg JKE-1674 CAS: 2421119-60-8 JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and an active metabolite of GPX4 inhibitor ML-210. JKE-1674, an analog of ML-210 in which the nitroisoxazole ring is replaced with an α-nitroketoxime. JKE-1674 can convert into a nitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in a manner that is equipotent to ML-210 and is completely rescued by ferroptosis inhibitors. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![Medchemexpress LLC 1-[(2R)-1-methylsulfonylpropan-2-yl]-4-(trifluoromethyl)indole-5-carbonitrile | 1539314-06-1 | MFCD30343844 | 99.4% | 330.33 g/mol | C14H13F3N2O2S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000215247.png-250.jpg)
Medchemexpress LLC 1-[(2R)-1-methylsulfonylpropan-2-yl]-4-(trifluoromethyl)indole-5-carbonitrile | 1539314-06-1 | MFCD30343844 | 99.4% | 330.33 g/mol | C14H13F3N2O2S | 10 MG
GSK-2881078 is a nonsteroidal selective androgen receptor modulator (SARM) supplied as a high-purity research compound for preclinical pharmacology and biochemical assays. The compound is provided as a powder suitable for controlled storage and use as a reference standard in laboratory studies.
- Orally active nonsteroidal selective androgen receptor modulator used in muscle wasting research.
- High purity research-grade powder (99.4%).
- Molecular formula C14H13F3N2O2S; molecular weight 330.33 g/mol.
- CAS number 1539314-06-1 for unambiguous identification.
- Recommended storage: powder at -20°C for long-term, 4°C for short-term.
- Supplied in 10 mg quantity suitable for small-scale assays.
- Suitable as a reference standard in pharmacology and ADME studies.
Cayman Chemical VPMp15trIfluoroacetAT sal 5mg
A peptide ADGRG2 agonist; induces cAMP accumulation in HEK293 cells expressing human ADGRG2 (EC50 = 1.41 µM)
Apexbio Technology LLC Acitretin 55079-83-9 10mM (in 1mL DMSO)
Acitretin (CAS 55079-83-9) is a synthetic aromatic retinoid acting as an agonist of nuclear retinoic acid receptors (RARs) It is designed to modulate gene transcription thereby influencing cellular differentiation and proliferation Acitretin exerts its biological activity primarily through binding and activating RARs affecting retinoid signaling pathways involved in keratinocyte differentiation and epidermal proliferation Based on these pharmacological properties Acitretin holds research potential in the study of psoriasis other dermatological disorders and Alzheimer s disease
AdipoGen Opaganib
Chemical. CAS 915385-81-8. Formula C23H25ClN2O. MW 380.9. Opaganib is a selective inhibitor of sphingosine kinase 2 SPHK2 Ki = 9.8 μM, a lipid kinase that catalyzes formation of the lipid signaling molecule sphingosine 1-phosphate S1P. S1P promotes cancer growth, and proliferation and pathological inflammation, including TNF-α signaling and other inflammatory cytokine production. By inhibiting the SK2 enzyme, opaganib blocks the synthesis of S1P which regulates fundamental biological processes such as cell proliferation, migration, immune cell trafficking and angiogenesis, and is also involved in immune-modulation and suppression of innate immune responses from T cells. Opaganip has similar potency toward sphingosine kinase SK2 and dihydroceramide desaturase DES1.
Medchemexpress LLC ONC212 | 1807861-48-8 | 99.86% | 440.46 | 25 MG
ONC212, a fluorinated-ONC201 analogue, is a promising anti-cancer agent and a selective agonist of GPR132. It also induces apoptosis.
- Fluorinated-ONC201 analogue.
- Promising anti-cancer agent.
- Selective agonist of GPR132.
- Induces apoptosis.
Medchemexpress LLC Phenylglyoxylic acid sodium | 43165-51-1 | 99.9% | 172.12 | 500 MG
Phenylglyoxylic acid sodium is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in humans. It can also be used as a drug intermediate for the synthesis of antineoplastic compounds. Studies show that Phenylglyoxylic acid sodium exhibits anti-inflammatory activity in rats in a formalin-induced paw swelling model.
- Metabolite of ethylbenzene and styrene (EB/S)
- Biomarker for exposure to EB/S in humans
- Drug intermediate for the synthesis of antineoplastic compounds
- Exhibits anti-inflammatory activity in rats
Cayman Chemical ANTIBODY XL388 5mg
An orally bioavailable and ATP-competitive inhibitor of mTOR (IC50 = 9.9 nM); selective for mTOR over a panel of more than 140 kinases, including various PI3Ks (IC50s = >3,000 nM); inhibits mTORC1 and mTORC2 in vitro (IC50s = 8 and 166 nM, respectively); induces cytotoxicity in MG-63, U2OS, and Saos-2 osteosarcoma and 786-0 kidney cancer cells and increases apoptosis in 786-0 and MG-63 cells; induces cell cycle arrest at the G1 phase and increases autophagy in MG-63 cells; reduces tumor growth in an MCF-7 breast cancer mouse xenograft model at 50 and 100 mg/kg; inhibits phosphorylation of mTORC1 and mTORC2 substrates p70S6K, S6, 4E-BP1, and Akt in MCF-7 and PC-3 xenograft tumors at 100 mg/kg; reduces tumor growth in U2OS and 786-0 mouse xenograft models at 20 mg/kg
Cayman Chemical ANTIBODY K858 25mg
An inhibitor of Eg5 (IC50 = 1.3 µM); inhibits growth (GI50 = 0.98 µM), induces mitotic arrest (EC50 = 1.6 µM), and activates caspase-3 (EC50 = 1.6 µM) in HCT116 cells; selectively induces mitotic cell death in HCT116 cells over non-cancerous ARPE-19 retinal pigment epithelial cells; reduces tumor growth in an A2780 ovarian cancer mouse xenograft model at 150 mg/kg
Medchemexpress LLC BMS-986121 | 313671-26-0 | 99.96% | C15H9Cl2N3O2S | 1 ML
BMS-986121 is a positive allosteric modulator (PAM) of the μ opioid receptor, derived from patent WO2014107344. It is constructed on a chemical scaffold that represents a novel chemotype for μ receptor PAMs. For research use only.
- Positive allosteric modulator of the μ opioid receptor
- Augments β-arrestin-recruitment response
- Increases inhibition of forskolin-stimulated adenylyl cyclase activity
- Produces leftward shifts in the potency of endomorphin-I and leu-enkephalin
- Appears as a light yellow to yellow solid
- Store powder at -20°C for 3 years, 4°C for 2 years
- Store in solvent at -80°C for 6 months, -20°C for 1 month
Cayman Chemical ANTIBODY CAY10753 1mg
A TNKS2 inhibitor (IC50 = 0.3 nM); selective for TNKS2 over TNKS1 (IC50 = 6.1 nM), as well as PARP1 and PARP2 (IC50s = 89.6 and 37.8 nM, respectively); inhibits proliferation of DLD-1 cells at 1 µM
AdipoGen YC-1 (25 mg)
Chemical. CAS: 170632-47-0. Formula: C19H16N2O2. MW: 304.4. Nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator. Induces concentration-dependent increase in cGMP levels. Inhibits platelet adhesion to collagen. Thombosis inhibitor. Non-specific phosphodiesterase inhibitor. Na+ channel blocker. Anticancer compound. HIF-alpha inhibitor. Blocks angiogenesis. Tumor growth inhibitor. Apoptosis inducer. NK cell differentiation enhancer. TRAIL sensitizer.
Medchemexpress LLC Tofacitinib citrate | 540737-29-9 | 99.9% | 504.49 | 5 MG
Tofacitinib citrate (Standard) is an analytical standard primarily used for research and analytical applications. This compound acts as an orally available JAK1/2/3 inhibitor, demonstrating activity against bacterial, fungal, and viral agents.
- Orally available JAK1/2/3 inhibitor.
- Exhibits antibacterial, antifungal and antiviral properties.
- Suitable for qualitative and quantitative research experiments.
- Utilized in analytical techniques such as HPLC, GC, and MS.
Research Products International Corp 17-DMAG, 5 MG
17-DMAG (17-Dimethylaminoethylamino-17-demethoxygeldanamycin) is a synthetic derivative of the antibiotic geldanamycin. It belongs to the class of compounds known as Hsp90 (heat shock protein 90) inhibitors. Heat shock proteins, including Hsp90, play a role in cellular processes and are involved in the folding and stabilization of other proteins, known as client proteins.
The primary function of 17-DMAG is to inhibit the activity of Hsp90, leading to the degradation of client proteins that are dependent on Hsp90 for stability. Many of these client proteins are involved in signaling pathways and cellular processes associated with cancer, making 17-DMAG a valuable compound in cancer research.
Medchemexpress LLC L-glutamic acid-13C | 115473-51-3 | MFCD00190316 | 99.0% | 148.12 g/mol | C5H9NO4 (13C-labelled, one 13C) | 5 MG
L-Glutamic acid-13C is a stable isotope-labeled form of the amino acid L-glutamic acid, provided as a solid for laboratory use. It serves as an isotopic tracer or internal standard in metabolic studies and analytical workflows, including NMR and mass spectrometry, and is typically supplied in small vial quantities for research applications.
- Stable 13C label for tracing studies.
- Suitable for NMR and mass spectrometry applications.
- Solid powder form for convenient storage and handling.
- High isotopic enrichment supports quantitative analysis.
- Available in small quantities for method development and pilot experiments.